Organic chemistry – Page 11
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ResearchFirst GPT-4-powered AI lab assistant independently directs key organic reactions
Large language model takes control after being prompted to do Suzuki and Sonogashira couplings
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OpinionExploring new fragments of chemical space
How medicinal and process chemists are working together to build better drugs
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ResearchFast flow-chemistry set-up facilitates sulfur-fluoride click chemistry
A modular method makes the most of flow-chemistry to create click-ready reagents selectively and efficiently
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FeatureCubanes help drugs take the strain
Medicinal chemists are increasingly exploring strained ring systems, George Barsted reports, believing they can serve as replacements for conventional building blocks in pharmaceuticals
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CareersThe chemists creating knowledge-sharing websites
Speeding up scientific progress by sharing organic chemistry techniques, lab safety resources and computational procedures
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CareersOnline resources for chemists
A selection of tools, databases and advice sites to support your research
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ResearchNew silicon-based protecting group removable with blue light
Benzoyldiisopropylchlorosilane protects primary, secondary and tertiary alcohols, and also works alongside other protecting groups
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FeatureThe mechanical side of bonding
Synthetic chemists are finally mastering the assembly of interlocked molecules held together by the mechanical bond, find James Mitchell Crow
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FeatureReaching into the non-covalent toolbox
Alongside supramolecular stalwarts, budding bonding forms are vying to be valuable, finds Andy Extance
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NewsFuture House wants to build an AI biologist. They’re looking to a chemistry LLM for inspiration
ChemCrow has already recorded success researching, designing and producing an insecticide on its own
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ResearchSkeletal editing that simply swaps aromatic carbons for nitrogens will aid drug discovery
Atom-swapping chemistry gains two new techniques that are ready to use
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ResearchPlasma–microdroplet fusion enables catalyst-free amine alkylations
Microdroplet chemistry improves selectivity of plasma-mediated alkylation reactions
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OpinionSlow march of the retrosynthesis robots
Software synthesis suggestions are hampered by biased and incomplete datasets
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ResearchElusive crystals provide structural evidence of global aromaticity in a macrocyclic hydrocarbon
Reduced forms of [24]paracyclophanetetraene provide fresh understanding of redox-based aromaticity switching
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ResearchActivating a chemical reaction by ‘flipping a switch’
A low-cost microfluidic reactor could cut the environmental footprint of synthesis by directing electrons via an external electric field
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ResearchUnexpected oscillations clarify mechanism of 100 year-old Fischer–Tropsch reaction
Discovery could pave the way to improved design of catalysts
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ResearchSimple substitution creates subset of rhodamine fluorophores with extreme solubility
Tetramethyl-substituted 3-phosphonorhodamines look set to find use in cellular imaging
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ResearchElectrophilic aromatic bromination study casts doubt on textbook intermediate
New computational evidence that electrophilic aromatic bromination actually occurs via an addition–elimination mechanism
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ResearchMOFs offer safer solution for handling fluorinated gases that can ‘tame the tiger’
Compounds vital in medicinal chemistry and imaging can be stored ready to use at room temperature
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ResearchEncapsulation drives visible light isomerisation in azobenzene photoswitch
Efficiency and selectivity of photoswitches boosted by confining light-sensitive structures into supramolecular capsules