Organic chemistry – Page 11
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ResearchRadium chelator researchers working to improve targeted cancer therapies
Oak Ridge National Lab team investigate factors underpinnning Ra2+ complex stability and selectivity in attempt to expand the therapeutic utility of radium-223
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OpinionEmbracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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ResearchMystery surrounding metalation reaction’s reagent excess solved
Multiple ‘base-eating’ aggregates discovered in classic directed ortho lithiation
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ResearchQuantum chemical analysis uncovers previously overlooked contributor to carbocation stability trend
Introducing substituents destabilises the parent substrates
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ResearchGigantic database of building blocks will help artificial intelligence uncover new organocatalysts
Publicly available dataset containing thousands of structures could help chemists develop data-driven reaction optimisation methods for organic synthesis
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ResearchAI beats human experts when it comes to peptide design
Algorithm throws up some counter-intuitive structures in contest
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ResearchDual use molecular motor can drive or glow
Infrared light can flip molecular machine between rotary motion and photoluminescence
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ResearchFully automated synthesis robot sets new record in stereospecific carbon–carbon bond formation
The robotic platform can make six carbon–carbon bonds without human guidance
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ResearchChirality-flipping reaction could completely change total synthesis strategies
Photocatalytic reaction that inverts configuration of chiral carbon centres offers new stereochemical editing logic
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ResearchControversy surrounds corrected chemical structures
Researchers used machine learning-powered NMR prediction to correct improbable structures – but some of their revisions have been challenged
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ResearchAI discovers the best general conditions yet for cross couplings, doubling yields
Algorithm works with robotic experimenter on tricky Suzuki–Miyaura reactions
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ResearchChemical Turing machine reads molecular tape
Crown ether ratchet reads out molecular strand’s chirality
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FeatureWhen will molecular electronics make the connection?
Computer chips based on single molecules may remain a work in progress, finds James Mitchell Crow but the technologies developed along the way are being used by chemists to explore their reactions
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FeatureHow click conquered chemistry
Katrina Krämer tells the story of how click and bioorthogonal chemistry came to win the 2022 Nobel prize
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ResearchAmide library created at speed with machine learning and stopped-flow chemistry
Approach used 90% less starting material than continuous flow equivalent
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OpinionNobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
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OpinionDavid MacMillan: ‘The medal is the real celebrity’
The Nobel prize-winner on the joys of handing out his medal to everyone, chatting with William Shatner and Alex Ferguson, and the pain of being a Scottish football fan
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ResearchBlood could supply haem centre for biomass-supported catalyst
Haemoglobin-derived catalyst used to reduce nitroarene into aromatic amines