Biology – Page 19
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ResearchCrispr editing of certain genes could trigger cell death
Researchers identify more than 3000 spots in the human genome where gene editing could cause toxic side effects and genomic instability
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WebinarFinding new medicines for malaria
Join Chemistry World for this interactive webinar and explore some of the collaborative avenues of research looking for new medicines to prevent and treat one of our oldest foes.
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ResearchArtificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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ResearchRedox flow batteries charge up with peptide-based electrolytes
Study shows how electrolytes could be degraded using acid and heat
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ResearchRotting fish experiments reveal how organs fossilise
Most fossils are bones, but individual organs’ biochemistry determines whether they are preserved in rock
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FeatureCultured meat flexes its muscles
Rebecca Trager examines an emerging industry that is growing ‘meat’ outside of animals using cell lines cultivated in bioreactors
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OpinionWhy AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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ResearchTeixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
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NewsAlphaFold has predicted the structures of almost every known protein
Google offshoot DeepMind has released more than 200 million predicted 3D structures, covering nearly the entire protein universe
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ResearchTheories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
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ResearchMystery of how plants make strychnine solved 75 years after characterisation
Three-quarters of a century after Robinson and Woodward cracked structure chemists unravel poison’s biosynthesis
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ResearchRenewable rocket fuel made by genetically engineered soil bacteria
Bioengineered bacteria synthesise extremely energy dense cyclopropane chains
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OpinionAlzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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ResearchThe odour of amity: how you smell can predict friendships
Strangers who smell alike tend to form an instant connection with each other on first meeting
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ResearchEncapsulated bacteria show promise as injectable living drugs factories to treat diseases
Engineered E. coli produce insulin and vaccines in vivo
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OpinionFrom prebiotic soup to fine-grained RNA world
Theories about how life emerged need to be closely attuned to conditions on the early Earth
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ResearchLight-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
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ResearchFossil molecules reveal dinosaurs’ bird-like metabolism
Thioethers preserved in bones show that most dinosaurs were warm-blooded, though T rex may have been particularly sluggish
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