Drug discovery and development – Page 13
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NewsOpen source antiviral dataset released to aid fight against Covid-19
CAS collection hosts 50,000 compounds with potential to treat coronavirus infections
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NewsPublisher expresses reservations about hydroxychloroquine study it printed
Study claimed malaria drug could treat Covid-19
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PodcastRemdesivir
Will new clinical trials for Covid-19 give remdesivir a second chance? Ben Valsler introduces the broad-spectrum antiviral that didn’t quite make it as the Ebola drug it was originally planned to be
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ResearchStructural studies offer glimpse of how coronavirus initiates human cell invasion
Researchers studying virus receptor-binding domains suggest virus could have passed directly from bats to humans
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OpinionVaccine development against the clock
How long will it take to develop a coronavirus vaccine and why is it so hard?
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BusinessCan existing drugs slow Covid-19?
The fastest route to treatments may be to repurpose existing drugs – if they work
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PodcastChloroquine and hydroxychloroquine
The Covid-19 pandemic – and some very high profile backing – has led to malaria drugs chloroquine and hydroxychloroquine hitting the headlines worldwide.
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ResearchPotent coronavirus drug candidate designed using 3D structure of key viral enzyme
Inhibitor of Sars-CoV-2 protease shows promise in early animal tests
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NewsUK researchers receive £20m to start coronavirus treatment research
Two vaccine trials among six projects that win funding
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ArticleMetathesis enables everyday innovation
For process chemists, simple solutions to complex problems are crucial. Metathesis is a cost-effective, reliable and scalable tool that enables innovation
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ArticleMarrying personalised medicine with the mainstream
By eliminating waste and confronting supply chain issues, the Medicines Manufacturing Innovation Centre is bringing personalised medicine to healthcare
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ResearchTargeted nanoparticles swell-up to kill cancer cells
Nanoparticles covered with charged ligands can kill errant cancer cells but leave normal cells unharmed
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PodcastMinoxidil and Finasteride
Catherine Hodges explores the chemical solutions to thinning hair and patchy beards, examining the popularity of minoxidil and the cautionary tale of finasteride
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BusinessRNA vaccines are coronavirus frontrunners
Several groups have potential Sars-CoV-2 vaccines ready or close to testing, thanks to rapid development pathways
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ResearchCheating bacterium becomes antibiotic-tolerant at expense of other species
Coexistence triggers counterintuitive antibiotics response in bacteria, which could be used to tackle hardy species
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ResearchMetal complexes outperform organics in antimicrobial analysis on crowdsourced compounds
Could this study prompt drug developers to rethink their reluctance to making metal-based pharmaceuticals?
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ResearchAI tool screens 107 million molecules, discovers potent new antibiotics
Deep learning approach could help in fight against drug-resistant bacteria
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ResearchDetailed 3D coronavirus spike map offers hope for vaccine development
Structure determined at ‘remarkable’ speed in little over a month
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OpinionTwo heads are better than one
Bifunctionals show that sometimes simply tethering two useful molecules together unlocks some useful activity