Medicinal chemistry – Page 17
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PodcastGlycyrrhizic acid
A sweet treat with a deadly trick for Halloween – glycyrrhizic acid is found in black liquorice and sweeter than sucrose, but can cause heart problems and even prove fatal if consumed in excess
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OpinionEthical challenge
Should researchers infect healthy people with Sars-CoV-2 to speed up vaccine testing?
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FeatureEngineering a handshake for proteins
Once considered undruggable, chemists are beginning to grasp protein–protein interactions, according to Ian Le Guillou
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ResearchPeptides self-assemble to support growth of artificial tumours
Cancer cells grown around bioengineered microfibres make an ideal model to test new chemotherapy drugs
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ResearchFast-acting insecticide polymorph could boost malaria-control efforts
Recrystallised deltamethrin accelerates uptake in mosquitoes
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NewsFirst Covid-19 challenge study working with live virus planned for the UK
Pending ethics panel approval, healthy volunteers would be infected with Sars-CoV-2 to help understand disease and test vaccines
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ResearchSalt bridge strategy expands access to pharmaceutical cocrystals
New approach to cocrystallisation could lead to exciting multi-drug combinations
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PodcastSofosbuvir
The hepatitis C drug that made waves when first launched – quicker to work and with fewer side effects than existing drugs, but it came with a hefty price tag
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NewsChemistry at work in e-liquids is still poorly understood, worrying researchers
New compounds with potentially harmful effects on the lungs can form from the mixture of flavours and solvents – even at room temperature
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NewsNew Covid-19 test doesn’t need reagents that are in short supply
US researchers develop a two-step test for the novel coronavirus that doesn’t requires the use of scarce reagents
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PodcastBedaquiline
The first TB drug approved in 40 years gave hope to sufferers of drug resistant tuberculosis and ushered in a new class of antibiotics
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OpinionBlood offering
Antibodies in various forms could bridge the Covid-19 treatment gap until a vaccine is available
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OpinionJumping the vaccine queue
Deals between companies and rich governments offset manufacturing risks, but must not compromise supplies to those in need
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BusinessCovid-19 vaccine deals risk skewing supply
International accords including Covax aiming to ensure equitable distribution to poorer countries
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WebinarDeveloping small-molecule degraders using chemoproteomics
Discover how chemoproteomics can inform the development of small molecule degraders
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FeatureHuman chemical communication
Nina Notman sniffs out the evidence for human pheromones and chemical cues
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BusinessProtein-based Covid-19 vaccines could overshadow rivals
Although slower to develop, protein-based vaccines are well understood with a strong record of safety and effectiveness
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ResearchDNA-compatible C–H activation method set to benefit drug discovery
Larger and more diverse DNA-encoded libraries on the cards thanks to new tool
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NewsRush to approve Covid vaccine prompted by politics may end in disaster
Push by governments to pass a vaccine without appropriate evidence could damage fight against virus
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BusinessRussian Covid-19 vaccine data raises questions
Suspected data manipulation or fabrication casts shadows over safety trial report for hastily-approved Sputnik V