Structural sleuthing salvages superbug slayer

Model of a mineral crystal structure

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Combining ‘assembly line’ synthesis, spectroscopy and computational predictions solves stereochemistry riddle

After failing to make the superbug-fighting molecule baulamycin, UK researchers have overturned the chemical structure it was originally assigned. Varinder Aggarwal and colleagues at the University of Bristol had been trying to make both baulamycin A and B using the ‘assembly line synthesis’ approach they developed. But the method would also provide answers to a challenge arising from the baulamycins’ exotic origins.