Organic chemistry – Page 25
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ResearchSteric shield leads boron to aromatic rings’ most remote region
Bulky blocking counterion makes quick work of borylating arenes’ inaccessible para position
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Opinion(±)-Rhabdastrellic acid A
A triterpene that looks innocuous until it reveals the highly strained conformation of its rings
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ResearchLight intensity changes can switch photocatalyst between one- and two-photon mechanisms
Simple optical lens behind strategy for manipulating photochemical reactivity
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ResearchLignin and carbon dioxide turned into ethanol
Process generates bulk chemical from two renewable carbon sources
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ResearchMystery of whether or not kekulene is superaromatic unravelled after 41 years
Second-ever synthesis and first atomic resolution images of superbenzene reveal its electronic nature
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PodcastCiguatoxin
The toxin found in reef fish that leads to food poisoning so bad it can cause life-long symptoms
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ResearchCarbynes expand the possibilities of carbon–carbon double bonds
Chemists use novel monovalent carbon species to insert functionalities in the middle of double bonds
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ResearchAlzheimer’s therapy has click chemistry use, then remove, brain copper build-ups
In situ drug synthesis catalysed by endogenous copper
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ResearchMetallohelices emulate antimicrobial peptides
Scientists move away from traditional drug candidates to evade resistance
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ResearchSynthetic flame retardant compounds turn up as marine natural products
Finding an alga that biosynthesises halogenated anilines increases likelihood of finding an organism that can degrade the toxic compounds too
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OpinionStille cross-coupling
Palladium and tin combined to lay the foundations for a revolution in C–C bond-forming reactions
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ResearchFirst synthesis of unusual natural product could revive forgotten eco-friendly insecticide class
16-step synthesis of rare diterpene could reveal new ways to control insecticide-resistant pests
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ResearchTemplate molecules round-up extra-large cyclodextrins from enzymatic synthesis
Scientists rethink how they use enzymes in chemical synthesis by exerting thermodynamic, rather than kinetic, control
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ResearchUniversal method bypasses obstacles to making neglected hydrocarbon skeletons
Universal method bypasses obstacles to making neglected hydrocarbon skeletons
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OpinionEmbracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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ResearchHuman biases cause problems for machines trying to learn chemistry
Including ‘unpopular’ reagents and reaction conditions into datasets could lead to better machine-learning models
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OpinionStereoselectivity with a twist
Helical ligands amplify solvent chirality to control reaction outcomes
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ResearchSolution to 120 year-old puzzle reveals new chemical phenomenon
Seemingly identical acetaldehyde phenylhydrazone crystals melt at different temperatures
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ResearchGiant tree molecule made out of 45 rotaxanes switches size on demand
Mechanically interlocked molecules give dendrimer the ability to expand and contract