Organic chemistry – Page 27
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PodcastVitamin B12 or Cobalamin
If you’re trying out a vegan diet, you’re likely to be told to make sure you get enough vitamin B12. But what is B12, where do we get it from, and how can we be sure we’re getting enough?
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ResearchProgram finds 5 million synthetic routes to complex chemicals
Only around five hundred ‘tactical combinations’ for advanced organic synthesis existed – until Chematica was let loose on the problem
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Feature
Can chemists crack our cells’ sugar code?
Rachel Brazil talks to the scientists trying to understand the sweet mystery of the glycome
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ResearchTotal synthesis of H. pylori antigen creates starting point for gastric cancer vaccine
Remote participation strategy helps chemists make sterically-congested repeating fragment
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PodcastIminosugars
After some promising results treating ill pets, some researchers think iminosugars could become treatments for infection and even cancer. Mike Freemantle explores the buzz around iminohoney
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ResearchSimple way to construct molecules with perfluoroalkyl bridges
Troublesome side reaction becomes useful synthetic tool
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NewsOpen access Atlas maps out microbial natural products
Project aims to accelerate research on microbial metabolites
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OpinionCleaning up chemical kitchens
In a busy plant, ensuring small changes don’t produce unforeseen toxic impurities is key
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ResearchSupramolecular mask simplifies fullerene modification
Porphyrin structure makes it easier to perform selective reactions on fullerene substrates
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ResearchFlow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
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FeatureSeparating turmeric fact from fiction
Thousands of papers have been published on curcumin’s healing potential, but its usefulness is not yet proven, finds Andy Extance
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PodcastBeta-damascenone
Louise Crane explains how a series of happy accidents led to the discovery of this rose-scented compound, found in rose oil, beer, apple pie and Kentucky bourbon.
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ResearchTotal synthesis of unnatural enantiomer renews interest in quinine
Scientists hope their strategy will invigorate cinchona alkaloid-mimic catalysis
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ResearchChemists taken aback as dinitrogen found to speed up some reactions
Warnings that nitrogen should no longer be considered just an inert carrier gas
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ResearchBiomimetic synthesis cultivates yellow poppy pigment
Cascade process that fuses indole with orientalin verifies biosynthesis of nudicaulins
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ResearchSteric shield leads boron to aromatic rings’ most remote region
Bulky blocking counterion makes quick work of borylating arenes’ inaccessible para position
