Organic chemistry – Page 22
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ResearchMachine-designed natural product syntheses pass ‘Turing test’ for chemistry
Software updates allow Chematica to design sophisticated synthetic pathways, planning each step four or five moves ahead
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ResearchElusive formyloxyl radical hints at unique, and more sustainable, chemical transformations
An electrocatalytic route for forming the formyloxyl radical in situ enables researchers to probe its unexpected chemistry
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ResearchPorphyrin assembly is ‘largest pure organic synthetic cage’ ever made
Hollow structures could find use in light harvesting or cargo-trafficking systems
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ResearchTraditional olefin hydroboration yields surprising trans-isomers
A very common organic reaction under ordinary conditions has produced significant amounts of unexpected trans-products for the first time
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PodcastGlycyrrhizic acid
A sweet treat with a deadly trick for Halloween – glycyrrhizic acid is found in black liquorice and sweeter than sucrose, but can cause heart problems and even prove fatal if consumed in excess
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ResearchHammett equation parameters optimised for improved predictive power
Update overcomes limitations and eliminates human biases intrinsic to the original formulation
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ResearchDiels–Alder study casts doubt on innate endo-selectivity
New evidence questions the Alder endo rule of simple Diels–Alder reactions
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ResearchSuperbenzenes now do the twist too
Supertwistacene is the first configurationally stable chiral graphene nanoribbon
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ResearchUniversal chemistry software can turn words into chemicals
System could be the beginning of a brave new world of democratised chemistry
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ResearchChiral benzyne made with single handedness for the first time
First enantioenriched aryne atropisomer can create chiral nanographene and anthracene structures
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OpinionFully automated synthesis of fluorine-18 PET tracers
Making radioisotopes suitable for positron emission tomography
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ResearchAlgorithm discovers how six simple molecules could evolve into life’s building blocks
Program shows how micelles, catalysts and self-replicating chemical systems emerge from abiotic precursors
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ResearchChemistry Nobel predictions range from organometallic chemistry to DNA synthesis
Crispr is favoured by chemists while publication analysis forecasts winners working on nanocrystals, organometallic chemistry and supramolecular self-assembly
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FeatureDirect observation of the transition state
The mystery of precisely what happens when one chemical reacts to form a new one is now being revealed in ever greater detail
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FeatureHomogeneous C–H activation
In the final instalment of our grails series we look at how picking and choosing which bond to target holds the promise of transforming organic molecules at will
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ResearchCarbon bond formation reproducibility runs into reagent stability problem
Solid sodium alkoxides react with carbon dioxide and can hamper performance – but sometimes improve it
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ResearchDNA-compatible C–H activation method set to benefit drug discovery
Larger and more diverse DNA-encoded libraries on the cards thanks to new tool
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ResearchRetro-Diels–Alder study links solvent viscosity to reaction rate under microwave heating
New study helps to establish the parameters for microwave-specific rate enhancements observed in certain reactions
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ResearchHybrid light–matter particles offer tantalising new way to control chemistry
Early experiments are revealing that vacuum-field catalysis could make reactions happen with mirrors and nothingness