Francis Crick Institute

Out of the suburbs: the rise of urban labs

Could empty office blocks and shopping centres provide much-needed space for growing companies?

Norman Keane

The hole in the UK chemical industry

Norman Keane thinks ICI’s breakup has left a gap in scale-up knowhow and skills, as well as a lack of facilites

Chris Kay

The problem of scale-up in the UK

What’s the point of knowledge generation if we’re not creating high value jobs, asks Chris Kay

Ordered blocks and a disordered one

Polymorphs matter – especially when they might disappear

Disappearing polymorphs offer a fascinating example of the dark arts of crystallisation

Highlights

Mustard leaf salad

Making genetically engineered food palatable

The next generation of genetically altered food is forging ahead, aiming to be attractive to consumers rather than producers. Katrina Megget finds out whether Crispr means crisper salads

Tractor spraying glyphosate at sunset

The glyphosate debate

The EU has recently approved the use of glyphosate for another decade. Bárbara Pinho examines the controversial pesticide’s presence in British farming and considers the possibility of a ban in the UK

Graphic with large F and several bottles of pills

Putting the F in pharma

Adding fluorine to drug molecules can be tricky, but is often worthwhile. Rachel Brazil talks to the chemists trying to tame the ninth element

Closeup on a blister pack with male contraceptive pills

On the trail of the male contraceptive pill

As multiple novel male contraception compounds enter clinical trials, is family planning about to undergo a second revolution? James Mitchell Crow reports

Paper shredder shredding a protein structure

The promise of drugs that send proteins to the shredder

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to strategic discovery

Ordered blocks and a disordered one

Polymorphs matter – especially when they might disappear

Disappearing polymorphs offer a fascinating example of the dark arts of crystallisation

A photograph of a researcher wearing eye-protection, gloves and a mask, holding a vial containing an mRNA vaccine

Fears grow over the future of mRNA vaccine research in the US

Researchers working on mRNA vaccines fear federal funding might be halted, with many looking to move projects abroad

Zinc finger

Acceptable levels of (epi)genetic engineering

Amplifying or silencing genes may be preferable to permanently changing genetic code

Obsolete computer

The value of good software extends beyond its cost

Whether third-party or built in-house, thoughtful design and implementation can improve workflows and make science more inclusive

Zinc finger

Acceptable levels of (epi)genetic engineering

Amplifying or silencing genes may be preferable to permanently changing genetic code

29 dead in explosions at two illegal fireworks factories in India

Incidents in Gujarat and West Bengal highlight minimal oversight of hazardous industry

BioLab fined for fire and chemical plume at US plant

‘Improperly stored’ pool chemicals reacted with water to release chlorine

Government reduces UK Reach fees by ‘£40 million’

Registration fees for most chemicals reduced, but uncertainty remains over safety data requirements

Making genetically engineered food palatable

The next generation of genetically altered food is forging ahead, aiming to be attractive to consumers rather than producers. Katrina Megget finds out whether Crispr means crisper salads

I can’t believe it’s not…

The analytical techniques revealing the true identity of what you spread on your bread

Index

Improving propylene synthesis using light-activated catalysis could cut emissions

Single-atom photocatalyst makes propylene at milder temperatures

All-atom molecular dynamics simulation of peptide-membrane systems

Generative AI pipeline creates promising antimicrobial peptides

AI model extrapolates beyond training data to predict diverse antimicrobial structures

Pill dropped in water

Far more drugs could be taken orally by formulating them with silica nanoparticles

Many more medicines could be made water soluble making taking them easier for patients

Mapping metabolite disturbances by drugs

High-throughput metabolomic profiling gives insight into unpredictable drug effects

Metal–organic framework captures carbon dioxide at industrially relevant temperatures

Material could improve energy efficiency of capturing carbon from industy’s exhaust gases

Fluorspar to fluorine chemicals without going via hazardous hydrogen fluoride

Safer way to turn calcium fluoride mineral into valuable industrial materials

Banned pigments found in tattoo inks sold in the EU

Nine out of 10 green and blue inks analysed violate Reach regulations

Nanopore sequencing set to transform our understanding of proteins

Rapid sequencing technique can not only deal with proteins hundreds of amino acids long but can detect modifications

Norman Keane

The hole in the UK chemical industry

Norman Keane thinks ICI’s breakup has left a gap in scale-up knowhow and skills, as well as a lack of facilites

The problem of scale-up in the UK

What’s the point of knowledge generation if we’re not creating high value jobs, asks Chris Kay

BioLab fined for fire and chemical plume at US plant

‘Improperly stored’ pool chemicals reacted with water to release chlorine

Government reduces UK Reach fees by ‘£40 million’

Registration fees for most chemicals reduced, but uncertainty remains over safety data requirements

Trump’s tariff stand-off

Piling cost and complexity to stretched global supply chains will hit industries hard

Trump’s new tariffs threaten the chemicals sector

Broad and high tariffs could mean severe job losses and supply chain disruption for chemistry-using industries

Dow

Dow to cut 1500 jobs as global chemicals industry reshapes

US firm joins other industry heavyweights in shedding jobs to cut costs

Two miniature figures in suits standing on jigsaw pieces

J&J’s Intra-Cellular deal could signal more mega-mergers for 2025

£15 billion deal for neuroscience biotech aims to replace revenues from patent expiries

Doliprane Paracetamol

Sanofi spins out its consumer healthcare business

US-based investment firm takes controlling stake in Opella, while France’s government moves to ensure the company remains in the country

Materials analysis concept image from Anton Parr

Pass or fail: rapid polymer analysis with FTIR

Sponsored by

Your guide to quick and reliable verification of polymers with the Lyza 7000 FTIR spectrometer

Sigma-Aldrich SynLED Parallel Photoreactor 2.0

Illuminating progress: recent advances in photoredox catalysis

Sponsored by

In this free download, shed some light on the latest developments in photoredox for drug development and materials science

Molecules on abstract background

Digital tools for deft materials development

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Discover how Microsoft can help you turn years of lab work into days of computation