Organic matter – Page 6
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OpinionBack to basics for silylation
Karl Collins applauds the simplicity of adding silicon to heterocycles with KOtBu
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OpinionEnthralled by evaporation
A giant rotary evaporator is a mesmerising thing, says Chemjobber, but the plant requires a different approach
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OpinionRubriflordilactone A
Sometimes it’s worth building aromatics instead of buying them, says BRSM
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OpinionAlkynes reverse reactivity
A mild coupling of alkynes with thiol nucleophiles appeals to Karl Collins
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OpinionSynthesising the midnight oil
A chemical plant on a night shift is just as lively as through the day, says Chemjobber, but for different reasons
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OpinionLycopodium alkaloids
Not all natural products are created equal. BRSM looks at a flexible route to some perennial favourites
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OpinionTwisting activity from amides
When amides get out of shape, a whole new world of asymmetric aldol reactions opens up, says Karl Collins
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OpinionTrekking across chemical frontiers
You can’t shake a 1000 gallon reactor, says Chemjobber, so plant-scale hydrogenation is a challenge of phase boundaries
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OpinionPsylloborine A
Late stage dimerisation is a tantalisingly elegant but risky strategy for total synthesis, says BRSM
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OpinionShow the way but leave no trace
Karl Collins examines a stealthy strategy for directed C–H activation
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OpinionHow good do you want it?
Quality analysis is a very different ball game to a simple reaction check, says Chemjobber
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OpinionMandelalide A
New reactions need to belong in a synthesis, says BRSM, not be forced in for show
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OpinionRinging the changes
A chemical manufacturing plant is a whole new world compared to the lab, as Chemjobber explains
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OpinionIndoxamycins A, C and F
BRSM gets to the core of a divergent synthesis of this natural product family
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OpinionGone to completion
After a 66-step journey, Paul Docherty ponders the future of total synthesis in his final column
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OpinionMarcfortines B & C
Paul Docherty ponders a tasty cheeseboard as a source of synthetic inspiration
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