All articles by Chris Nawrat – Page 2

  • Organic Matter - Pavidolide
    Opinion

    (‒)-Pavidolide B

    2017-11-01T11:30:00Z

    An innovative approach to making five-membered carbon rings makes for a strikingly short synthesis 

  • 132232 Figure 1
    Opinion

    (+)-Pleuromutilin

    2017-07-19T12:24:00Z

    Total synthesis is sometimes the only way to explore the chemical space around a natural product

  • 0517CW - Organic Matter (zincophorin) - Fig1
    Opinion

    (+)-Zincophorin methyl ester

    2017-04-05T13:55:00Z

    New and old reactions combine for an elegant and concise synthesis

  • 0217CW Organic Matter - Main structure (closer crop)
    Opinion

    Thapsigargin

    2017-02-08T13:34:00Z

    A complex synthesis is always more impressive when conducted on gram scale 

  • 1116CW - Organic Matter - (+)-Psiguadial B
    Opinion

    Psiguadial B

    2016-11-10T17:37:00Z

    Flexibility and creativity help overcome unexpected obstacles

  • (–)-6-epi-ophiobolin N
    Opinion

    6-epi-Ophiobolin N

    2016-08-08T18:20:00Z

    When it comes to cascade reactions, radicals are king of the ring-formers

  • 0516CWOrgMatterF1
    Opinion

    Phorbol

    2016-05-05T00:00:00Z

    Sometimes improving synthesis requires a strategic re-think, says BRSM

  • 0216CW_OrgMatter_F1_300M
    Opinion

    Enigmazole A

    2016-02-10T00:00:00Z

    Although tricky to spot, rearrangements can simplify a synthesis, says BRSM

  • figure 1
    Opinion

    Batzelladine B

    2015-11-02T00:00:00Z

    Taming basic and reactive nitrogen atoms makes alkaloids more attractive targets, says BRSM

  • 0815CW_Orgmatter_F1_300m
    Opinion

    (–)-Jiadifenolide

    2015-07-27T00:00:00Z

    BRSM wonders what makes a route so good it becomes the last total synthesis of a complex target

  • CW0515_OrganicMatter_F1_300m
    Opinion

    Limaspermidine and deethylibophyllidine

    2015-04-27T00:00:00Z

    Desymmetrisation offers a neat way to add tricky features, says BRSM

  • Figure 1
    Opinion

    Rubriflordilactone A

    2015-01-28T00:00:00Z

    Sometimes it’s worth building aromatics instead of buying them, says BRSM

  • Figure 1
    Opinion

    Lycopodium alkaloids

    2014-10-29T00:00:00Z

    Not all natural products are created equal. BRSM looks at a flexible route to some perennial favourites

  • Figure 1
    Opinion

    Psylloborine A

    2014-07-30T00:00:00Z

    Late stage dimerisation is a tantalisingly elegant but risky strategy for total synthesis, says BRSM

  • Mandelalide structure
    Opinion

    Mandelalide A

    2014-05-08T00:00:00Z

    New reactions need to belong in a synthesis, says BRSM, not be forced in for show

  • Indoxamycins A, C and F
    Opinion

    Indoxamycins A, C and F

    2014-01-29T00:00:00Z

    BRSM gets to the core of a divergent synthesis of this natural product family