Medicinal chemistry – Page 20
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ResearchElectrochemical DNA on a chip sensor detects bacterial urinary tract infections faster
Synthetic nucleic acid probes combine with tiny star-shaped electrodes tests for bacteria in less than an hour
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OpinionOpening up a cellular black box
Working out how biomolecular condensates work may reveal a lot about the success or failure of different drugs
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BusinessSartan contaminant recall hits generics manufacturers
Three European suppliers recalling multiple batches of medicines owing to active ingredient contamination
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NewsRace to understand Sars-CoV-2 variants amid fears virus might evade vaccines
Biochemical basis behind coronavirus variants’ success could hold key to defeating them
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BusinessBMS and Eisai agree antibody-drug conjugate commercialisation deal
Companies will jointly develop cancer treatment, with BMS paying up to $3 billion for shared rights
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FeatureSupermetals versus superbugs
With pathogenic bacteria rapidly overcoming our arsenal of organic antibiotics, James Mitchell Crow asks if it is time to revisit metal-based antimicrobials
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BusinessRegeneron’s Covid-19 antibodies help those who can’t make their own
Regn-Cov2 reduces deaths and shortens hospitalisation for these patients, even when given at late stages of infection
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ResearchBlocking bacteria’s self-poisoning mechanism weakens their antibiotic resistance
Stopping bacteria from producing hydrogen sulfide in response to drugs could help overcome antimicrobial resistance
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BusinessAlzheimer’s antibody gets surprise US approval
Good news for industry and future drug approvals, but physicians doubt it will be effective for most patients
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OpinionFurin fundamentals
There’s no direct evidence for the lab leak hypothesis – and the biochemistry of the virus might not tell us much about it
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ResearchBiochemical mystery unfolds as elemental metals found in Alzheimer’s patients’ brains
In a discovery that raises more question than it answers, researchers have found zero-oxidation-state iron and copper deposits inside amyloid plaques
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ResearchProtein impurities found in AstraZeneca’s Covid-19 vaccine stir debate
Compounds might cause side effects but are unlikely to be behind extremely rare blood-clotting events
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NewsHints that century-old TB vaccine offers an immune boost against Covid-19
Small study is part of global effort examining whether the BCG jab could help in the next pandemic
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ResearchSynthetic overhaul for hepatitis C drug could ease manufacturing demands
Chemists hope their five-step synthesis will increase global accessibility of uprifosbuvir and other lifesaving antivirals
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BusinessMorphosys agrees to buy cancer epigenetics specialist Constellation
$1.7bn deal will be funded by selling rights to royalties on existing drugs
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ArticleSustainable safety testing
Unilever has been researching and applying alternatives to animal testing, and working with industry, academia, government scientists and NGOs to usher in a new era of sustainable safety testing that isn’t reliant on animal models.
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BusinessStriving to bolster the antibiotic pipeline before it becomes the next crisis
It’s been almost 10 years since the world was warned of a post-antibiotic apocalypse. Katrina Megget takes a look at the initiatives trying to support antimicrobial R&D
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ResearchPollen-mimicking antidote saves bees after pesticide exposure
Calcium carbonate microparticles deliver detoxifying enzyme to bees’ guts
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NewsPromotion of Covid-19 pseudoscience by Indian government criticised as pandemic rages
Questionable therapies under study or promoted include prayer, breathing exercises and herbal medicines
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OpinionThe side effects of being unique
Even the largest clinical trials won’t capture all possible bad reactions to a drug – we need pharmacovigilance