Medicinal chemistry – Page 26
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WebinarWL Gore: Optimising production processes with Design of Experiments
Learn how WL Gore use definitive screening designs to analyse multiple factors and optimise production processes
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ResearchUnprecedented biosynthetic transformation found to connect antibacterial polyketides from ant microbiome
Study identifies enzymes that convert flat fasamycins into three-dimensional formicamycins
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ResearchAlgorithm devises synthetic contingency plans for Covid-19 drug
Retrosynthesis software tool can identify multiple synthetic routes that use inexpensive and diverse starting materials while avoiding patented methods
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NewsCaution urged as scientists await results of trial that finds steroid cuts Covid-19 deaths
Claims that 60-year-old drug dexamethasone dramatically lowers fatality rate of seriously ill Covid-19 patients await peer review
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FeatureThe difficulties of drugging our brains
Following the withdrawal of many large pharma companies from central nervous system research, Andy Extance finds new drug development patterns are emerging
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PodcastCimetidine
Mike Freemantle introduces the peptic ulcer treatment cimetidine, which – as Tagamet – became the first blockbuster drug
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ResearchMethod that yields oxygen-18-enriched alcohols set to bolster drug studies
Mitsunobu-based protocol is simple alternative to limited and lengthy methods
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OpinionCollaboration is key to AI-aided drug discovery
The AI Cures project shows how artificial intelligence can assist the search for a cure for Covid-19
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ResearchRespiratory viruses detected in 30 minutes with the help of a smartphone
$50 smartphone accessory could be adapted for Covid-19
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BusinessDeveloping antiviral mask technology in a pandemic
Surface chemistry strategies play a pivotal role in personal protective equipment that can neutralise the Sars-CoV-2 virus
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ArticleOptimising biotech processes
Fujifilm Diosynth Biotechnologies achieve both speed and scale through designed experiments
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PodcastFexinidazole
The World Health Organisation hope to eradicate sleeping sickness within our lifetimes. Jamie Durrani looks at a drug that may make it possible.
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ResearchDatabase offers another way to search for drugs – by activity not structure
Dataset offers new way for biomedical researchers to identify potential drug candidates
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FeatureDrugging the gut microbiome
Treating the bacteria that live inside us can improve our own health. Clare Sansom meets our tiny friends
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WebinarTeaching Design of Experiments to chemists: lessons from Imperial College London
First-hand experience from Imperial College London: Join us to learn about the importance and efficient implementation of a DoE training program in chemistry
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OpinionCovid-19 poses trust issues for science
The pandemic is proving the importance of public trust in science
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PodcastDMT – Dimethyltryptamine
Georgia Mills investigates the psychoactive found in ayahuasca that may mirror near-death experiences
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NewsVaccine manufacturing centre to be rushed into service a year early by UK government
Injection of new funding will mean centre opens in 2021 as licensing deal also agreed to boost vaccine capabilities
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BusinessHow Covid-19 is changing drug manufacturing
Catalent is adapting, focusing on employee safety and supply chain security
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BusinessThis little Crispr went to market
Gene editing technology heading towards commercial reality in pharmaceuticals, food and organ transplant