In depth

AI drug discovery

Benchmark flaws may be distorting AI drug-discovery leaderboards

Audit identifies subtle but consequential issues, such as conflicting labels and train–test leakage, in numerous benchmark datasets

HfO2

Combining AI with experiments to solve real-world materials problems

CuspAI’s Materials Foundry partner network includes 45 technology, data and materials chemistry companies to make and test its predictions

NSF

US National Science Foundation putting $380 million into building ‘self-driving’ labs

North Carolina State is one of the institutes receiving a $20 million grant aims to advance an autonomous chemistry lab

The structures of three different ring-shaped proteins. Each has an outer layer of helices and an inner layer of folded sheets.

Protein wrappers designed by AI solve membrane proteins’ solubility problem

Protein sheaths encapsulate membrane proteins while preserving their structure and function making them easier to study

AI model fills in the gaps in crystal structures by placing missing hydrogen atoms

Model may help fix existing structures in the database or better simulate new materials

Could AI research assistants speed up scientific discovery?

Google’s Co-Scientist and Futurehouse’s Robin can help scientists generate hypotheses, design experiments and analyse data

‘Human-in-the-loop’ approach could cut costs of robotic labs by 90%

Reducing costs may democratise field by making self-driving labs more accessible

Machine learning cuts complexity of computational calculations in catalysis

Software simulates 370,000 steps in under 100 hours, potentially cutting demand for time on supercomputers by orders of magnitude

Worldwide

Coal plant

EPA to revoke emissions limits on fossil fuel power plants

Trump administration estimates that its action will save over $300bn, but opponents criticise decision to ‘eliminate limits on climate pollution’

Climate change driving extreme acidification of North American streams that threatens life in them

Oxidation of sulfides in melting permafrost acidifies stream and leaches toxic metals from minerals

Could lab-grown cocoa be the solution to the climate and supply chain woes plaguing chocolate?

Companies are ready to begin supplying chocolate makers with cell-based cocoa powder in early 2027

Industrial emissions of feedstock chemicals are hindering recovery of ozone layer

Emissions of certain ozone-depleting chemicals could delay the ozone layer’s recovery by six to 11 years

Two children reading

The genius narrative isn’t inspiring – science biographies for children may send a demotivating message

Analysis of over 400 children’s books finds ideas around early interest in science and innate ability could turn young readers away from science

Hand drawing red dividing line separating groups of people

Socioeconomic background still holding back students in chemistry, RSC report finds

Access is only the first step to making the chemical sciences inclusive