Highlights

AI drug development

As AI-designed drug looks to pass final hurdle, will this tech change drug discovery forever?

AI-led drug for chronic lung disease set to enter phase 3 clinical trials, though experts remain divided on AI’s impact in pharma

Sudhakar Tasgave

‘I barely sleep for four hours’: Are pesticides robbing farmers worldwide of sleep?

Studies point to an emerging link between a range of pesticides and insomnia

Heat map

Chemistry ‘cold spots’ emerging across the UK, RSC warns

Some regions face a future with fewer chemists

Team photo

The startups that grew out of the Pfizer redundancies

18 months on, three former Pfizer employees explain how they’ve seized opportunities to fill gaps in the market

Fighter aircraft

Military demand strains metal supply chains

Conflict and trade disputes have disrupted global supplies of specialist metals like hafnium, antimony and rare earths

Scientist pipetting liquid into vials

Ion suppression correction and normalisation in metabolomics

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Join us on 5 November to learn new ways to improve data consistency with mass spectrometry

Sad liver

Liver toxicity remains an unpredictable hurdle for medicinal chemists

The liver’s complex role in metabolising drugs makes it both a critical consideration and potential stumbling block 

Argentina protest

Deadly fentanyl contamination exposes drug safety challenges

Bacterial conatmination in medical fentanyl has killed at least 51 people in Argentina, highlighting pressures on generic drugmakers

Lipid membrane modelled in yellow on a white background

Lipidomics for antibiotic resistance (AMR) mechanisms

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Join us on 23 October to discover how microbial antibiotic exposure triggers lipidomic changes, offering insight into how lipids contribute to resistance mechanisms

False nails

Why has the EU banned a key chemical in gel nail products?

Trimethylbenzoyl diphenylphosphine oxide is a photo-initiator used to harden nail polish under UV light

Deadly fentanyl contamination exposes drug safety challenges

Bacterial conatmination in medical fentanyl has killed at least 51 people in Argentina, highlighting pressures on generic drugmakers

At least 51 deaths in Argentina linked to tainted medical fentanyl

Investigation reveals history of regulatory failures as pharmaceutical company faces criminal charges over Argentina’s deadliest drug contamination scandal

Four dead after nitrogen leak at pharma factory in India

Incident at Medley Pharmaceuticals’ Boisar–Tarapur plant leaves two others in a serious condition

Negotiations to create a global plastic pollution treaty collapse again

Geneva meeting descends into chaos with hastily revised treaty text rejected by member states

DuPont and spin-offs settle with New Jersey over PFAS contamination

Proposed deal with the US state includes $875 million in damages, plus clean-up funds

Bingham Canyon

Unrecovered byproducts from US mines could meet the country’s demand for dozens of critical materials

Huge quantities of metals and other elements are discarded each year in mining waste

Drug production

Ten years on, pharma industry still testing for implausible alkyl sulfonate ester contaminants

Risk assessment for potential mutagenic side-products is still required by regulatory bodies, despite lack of evidence they form during drug production

Refinery

Polymer membrane separates hydrocarbons, offering alternative to distillation

Microporous membrane enables energy efficient chemical separations

Improving propylene synthesis using light-activated catalysis could cut emissions

Single-atom photocatalyst makes propylene at milder temperatures

Generative AI pipeline creates promising antimicrobial peptides

AI model extrapolates beyond training data to predict diverse antimicrobial structures

Far more drugs could be taken orally by formulating them with silica nanoparticles

Many more medicines could be made water soluble making taking them easier for patients

Mapping metabolite disturbances by drugs

High-throughput metabolomic profiling gives insight into unpredictable drug effects

Metal–organic framework captures carbon dioxide at industrially relevant temperatures

Material could improve energy efficiency of capturing carbon from industy’s exhaust gases

Liquid spills out of a rusty old barrel

India introduces new rules to tackle chemical contamination sites

New legislation provides a legal framework for assessment and cleanup of 189 named chemicals

Chemours ordered to immediately limit PFAS emissions into Ohio River

US judge grants injunction to reduce Gen-X discharges from West Virginia plant to permitted levels

DuPont and spin-offs settle with New Jersey over PFAS contamination

Proposed deal with the US state includes $875 million in damages, plus clean-up funds

Intergovernmental panel on chemicals, waste and pollution needs diverse input

Balancing industrial expertise against unwanted commercial influence is not easy but shouldn’t be discounted

11 executives jailed over Italian PFAS pollution

Convictions relate to groundwater contamination around Miteni fluorochemicals plant

Military demand strains metal supply chains

Conflict and trade disputes have disrupted global supplies of specialist metals like hafnium, antimony and rare earths

Sanofi

Sanofi to buy Blueprint Medicines for over $9 billion

Blueprint has one approved drug and enhances Sanofi’s immunology portfolio

Merck signage in Darmstadt

Merck KGaA to buy cancer specialist SpringWorks

$3.9 billion deal boosts Merck’s pipeline as it faces patent expiries

Cell culture in laboratory

Optimise drug discovery: predicting transporter-mediated drug interactions

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Learn how in vitro models, biomarkers and modelling can improve prediction of drug interactions and toxicity – reducing false positives and unnecessary clinical studies

Materials analysis concept image from Anton Parr

Pass or fail: rapid polymer analysis with FTIR

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Your guide to quick and reliable verification of polymers with the Lyza 7000 FTIR spectrometer

Sigma-Aldrich SynLED Parallel Photoreactor 2.0

Illuminating progress: recent advances in photoredox catalysis

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In this free download, shed some light on the latest developments in photoredox for drug development and materials science