Medicinal chemistry – Page 36
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ResearchNanoparticles offer extensive new cure for snakebites
Treatment neutralises venom, reducing tissue damage
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BusinessCleaning up clinical trials
Campaigns to enforce complete and correct reporting of trial data are beginning to take hold
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NewsWhat is directed evolution and why did it win the chemistry Nobel prize?
If you’ve got questions about yesterday’s chemistry Nobel prize then we’ve got answers
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NewsWhat is 'checkpoint therapy' and why did it win the medicine Nobel prize?
James Allison and Tasuku Honjo released the ‘brakes’ on our immune system to combat cancer
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NewsImmune-stimulating cancer treatment takes 2018 medicine Nobel
James Allison and Tasuku Honjo receive science’s highest honour for discovering how cancer stops immune cells from attacking
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ResearchHealthy animals mimic body odour of sick companions
Sniffer mice and chemical analysis suggest that sickness odours are contagious
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ResearchSimple test behind early cancer diagnosis breakthrough
Technique combines rolling circle amplification with time-gated Förster resonance energy transfer to detect cancer microRNA
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ResearchExotic amino acids made easy with radicals
Stereoselective radical coupling to rival classic Strecker synthesis for easy access to unusual amino acids
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BusinessLandmark China cancer drug full approval ‘first of a wave’
Chi-Med’s fruquintinib is a result of China’s evolving drug innovation and regulation
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FeatureThe nuclear option
Using radioisotopes to image inside patients’ bodies – nuclear medicine – is under threat from ageing reactors. James Mitchell Crow discovers the new science trying to fix the problem
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ResearchHepatitis C drug lead designed to target virus RNA
Gene-to-RNA-to-medicine pipeline possible thanks to technique that reveals interactions between RNA and small molecules
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NewsBitter feuding at Cochrane healthcare audit body paralyses organisation
One member has been expelled from the governing board while another four resign with accusations of pharmaceutical industry bias flying
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ResearchGenentech antibiotic quells resistance
Modified arylomycin combines high potency with new mechanism of action
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ResearchBlood markers link firefighters' lung disease to WTC attacks
Firefighters who developed lung disease after responding to 11 September attacks in New York connected to specific metabolic profile
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OpinionFeeding the confusion
When it comes to working out what foods do to our bodies, mostly we just don’t know
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FeatureThe quest to cure HIV
Although HIV–Aids can now be managed quite well with antiretroviral drugs, there is still no cure. Anthony King talks to the scientists trying to find one
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BusinessUS approves first RNA interference drug
Alnylam’s Onpattro (patisiran) can treat a rare hereditary disease by silencing a specific gene
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ResearchBismuth drugs kill bacteria by disrupting metabolism
Scientists throw kitchen sink of omics techniques at understanding complicated response of prevalent human pathogen to bismuth drug