Medicinal chemistry – Page 33
-
ArticleSmall particles making a big splash in clinical development
Nanoform is investigating how to tackle clinical attrition rates through nanonisation of APIs
-
ArticleInvestigating multi-dimensional problems in drug substance development
Finding solutions to the biggest challenges faced during drug substance development relies on properly integrating analytical and production expertise
-
ResearchHole-punching antifungal used as molecular prosthesis for cystic fibrosis
Drug creates artificial ion channels that could replace broken version in cystic fibrosis patients’ lung cells
-
PodcastVinblastine and vincristine: Vinca alkaloids
Kat Arney unearths a story of an overlooked female researcher in the search for the origins of cancer drugs found in plants
-
ResearchCopper mixes with alcohol abuse drug for anticancer action
Chemical model reveals how alcoholism drug disulfiram joins copper to kill cancer cells with oxidation overload
-
ResearchSmall molecule finds flu virus’s weak spot
Drug candidate that targets highly conserved region of virus gave mice complete protection from swine flu
-
FeatureThe battle to lose weight
Losing weight – and not putting it back on – is about much more than willpower. Nina Notman reports on the drugs trying to penetrate the complex metabolic web of hunger and satiety.
-
ResearchCracking enzyme structure offers new way to treat rare heart diseases
Solution was found by combining protein with its chaperone
-
BusinessSmartwound dressings spot infection early
Bacterial toxins burst dye-filled vesicles to give a visual warning
-
NewsUniversity sues professor for taking graduate’s research that he stands to make millions from
University of Missouri–Kansas City pharmacy researcher accused of stealing inventions related to a novel eye drug delivery formulation, sold it for $1.5m plus royalties
-
NewsGenome sequencing for healthy dismissed as waste of time for UK project
Personalised medicine plan unlikely to deliver any benefits for the wider population
-
ResearchGenetically engineered yeast brews up heady mix of natural and unnatural cannabinoids
Biotech yeast makes low-cost, high-quality THC and CBD – and cannabinoids never seen before – without growing cannabis plants
-
ResearchThe five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
-
-
FeaturePass the antidote
From paracetamol to pesticides – not to mention nerve agents – there are many toxic compounds that doctors need to be able to counteract. Nina Notman investigates
-
ResearchTwo flavouring chemicals prevalent in e-cigarettes might harm lung function
Diacetyl and 2,3-pentanedione suppress gene expression related to cilia production and function
-
PodcastMelarsoprol
Cases of sleeping sickness – human African trypanosomiasis – are in decline, dropping 86% in Africa between 2000 and 2014. Gege Li explores the role that this toxic, arsenic-based medication has to play.
-
NewsPersonalised medicine has failed to live up to the hype, researchers claim
Predictions that Human Genome Project would usher in an era of tailored therapies have largely failed to come true
-
OpinionHow teenagers are disrupting drug discovery
A citizen science project to improve access to malaria drugs
-
BusinessUK government sets out antimicrobial resistance plan
Aims to cut antibiotic use and explore financial incentives for pharmaceutical companies