Modified metallohelices show medical potential

Metallohelix architectures

Source: © Peter Scott/University of Warwick

Post-assembly click reactions on helical metal complexes produces biological activity akin to that of the arrow poison ouabain

A new way to make and diversify metal helicate compounds has opened up possibilities for their use in drug discovery. The late-stage modification method, developed by researchers from universities in the UK and the Czech Republic, has already created a compound with enzyme-inhibiting prowess akin to that of the arrow poison ouabain.