Medicinal chemistry – Page 46
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ResearchModified antibiotic beats superbug resistance
Adding functional groups to vancomycin gives it extra modes of attack against resistant bacteria
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PodcastFibrin and fibrinogen
From scabby knees to life-threatening strokes, this important protein is the fundamental link in the complex molecular chain that forms blood clots
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OpinionDrug pricing must be more transparent
Pricing is a complex issue - how can we make it clearer?
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FeatureDelivering gene therapy
After some well-publicised problems, gene therapy – delivering DNA into people’s cells using viruses – is booming, Anthony King finds
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OpinionHow safe should drugs be?
What does spotting new risks in approved medicines say about how effective regulators are?
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BusinessPollution from Indian drugmakers drives drug resistance
Areas around manufacturing sites still heavily contaminated with antimicrobials and breeding multidrug-resistant pathogens
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PodcastPropranolol hydrochloride
Stave off stage fright with a simple compound that revolutionised drug development
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NewsIndia's HIV/Aids law may bring relief to a million people
Legislation aims to tackle stigma of testing and treatment
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ResearchBlue nanoparticles mop up radioactive element
Nanosized Prussian blue formulation removes radioactive caesium from body faster than commercial treatment
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ResearchHow total synthesis is creating antibiotics
Macrolide synthesis could reinvigorate the antibiotic pipeline
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ResearchCatalyst puts chiral twist on phosphorus drugs
Simple molecule overcomes headache of phosphorus stereochemistry in antiviral drug synthesis
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FeatureWearable technology
The future of wearable gadgets will be tiny, flexible, skin-like devices capable of monitoring your health
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ResearchCrispr enables rapid disease detection
A Crispr enzyme that targets RNA can recognise Zika at minute concentrations
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Research15-minute test catches out flu virus
A cheap, portable setup to detect influenza viruses could help clinicians prescribe the right drugs
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FeatureCovalent inhibitor drugs
Exceptions to a long-held rule against chemically bonding to biological targets are powering new cancer medicines, finds Andy Extance
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NewsNews from the American Chemical Society meeting in San Francisco
News stories from the 253rd National Meeting & Exposition of the American Chemical Society
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ResearchMaple syrup enhances antibiotics
A phenol-rich mixture extracted from maple syrup allows much smaller doses of antibacterial drugs to achieve the same results
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NewsHow we are fighting tropical diseases
Repellents and vaccines are useful but still need further improvement
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PodcastMercuric chloride
Michael Freemantle traces the history of a highly toxic medicine: Mercuric chloride
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BusinessExpanding precision medicine beyond cancer
Exclusive interview with Koustubh Ranade, vice president of R&D at MedImmune