Medicinal chemistry – Page 46
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CareersThe trials and tribulations of drug discovery
The many pitfalls medicinal chemists face when creating a new drug
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ResearchPoison dart frog toxin made in mirror image
Toxin’s non-natural enantiomer offers new tool to probe nerve disorders
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PodcastBenzoyl peroxide
The blondest blonde, the whitest smile, the clearest complexion – all from one essential compound
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FeaturePersonalised skincare
Nina Notman explores some of the latest scientific approaches skincare companies are using in the quest to develop high-earning anti-ageing cosmetics
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ResearchDibrominated tag helps identify new natural products
New substance allows researchers to find new aldehyde- and ketone-containing natural products
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NewsWHO cancer agency criticised for outdated chemical risk methods
Criticism of carcinogenicity assessments that place processed meat in the same category as mustard gas
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PodcastPARP: Poly (ADP-ribose) polymerase
Kat Arney explains how a protein that repairs broken DNA holds the key to killing cancer cells – but only if you stop it from doing its job
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OpinionRegulatory tightropes
When lobbying and marketing clash with scientific evidence, regulators walk a fine line
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OpinionPutting chemistry back in biology
The chemical nature of biomolecular interactions can no longer be ignored
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ResearchDNA suitcases packed with gene therapy cargo
Nano-sized capsules can be unlocked to release drugs on demand
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PodcastGabapentin
Louise Crane documents the rise and fall of Gabapentin – from ‘wonder drug’ to illicit substance in just 50 years
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ResearchWhat's your nano poison?
Informatics tool helps researchers visualise complex toxicity datasets
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ResearchSepsis’ sticking point in for a shock
Simple microfluidic method helps detect life-threatening condition earlier
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BusinessLilly to buy Boehringer’s pet vaccines
Deal strengthens Lilly’s animal medicine division following recent acquisition
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ResearchConnectosomes smuggle drugs across membranes
Engineered vesicles could cut drug side-effects by delivering them straight into cells using cellular ‘airlocks’
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OpinionBooster shot
Zika and Ebola have highlighted the pharmaceutical industry’s ability to respond to critical needs
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FeatureDrugging the epigenome
Drugs that change how your genes are switched on or off could change how we treat many diseases, as Rachel Brazil discovers
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FeatureNew MRI contrast agents
With rising concerns over gadolinium, Anthony King looks at the alternatives under development
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NewsPharma giants commit to tackling antimicrobial resistance
Plan to tackle superbugs includes changes to manufacturing and sales incentives