Medicinal chemistry – Page 54
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ResearchRegulators have drug firms chasing phantom impurity
Mutagenic contaminants that supposedly form in sulfonic acid salts are highly unlikely to arise
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ResearchDrawing order from disorder to unravel Ebola’s lethality
Intrinsically disordered proteins may be vital in determining the deadliness of Ebola strains
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ResearchDNA inspires smart phospholipids
Liposomes made from synthetic nucleoside phospholipids could benefit drug delivery
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News
US spends billions annually on unreproducible preclinical research
Study estimates $28 billion spent yearly on preclinical research that can’t be replicated
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ResearchInjectable electronics unfold to monitor brain activity
Electronics a million times more flexible than the best currently available could transform patient monitoring
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ResearchMicrofluidic approach to personalised cancer treatment
Multiple myeloma drug response assay could be adapted for other cancers
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Research
Simple sensor can spot cancer markers in minutes
Test can rapidly detect mutant tumour nucleic acids in boost for personalised medicine
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OpinionMagic molecule modifiers
Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it
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ResearchTaking the lead on drug discovery
Making compounds that promise to become useful drugs has just become a little easier
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ResearchMalaria drug could cash in on green chemistry
Minimising acid and solvent toxicity brings surprising benefits in artemisinin production
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NewsRoadmap to reward pharma for creating new antibiotics unveiled
Report recommends large up-front payments and an innovation fund for blue skies research to tackle microbial resistance
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ReviewVenoms to drugs: venom as a source for the development of human therapeutics
Defanging chemistry
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NewsScientists call for ban on fluorinated chemicals
The Madrid Statement, signed by 200 scientists, urges consumers to avoid PFAS-containing products
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ResearchZombie cells may rise up to kill infections
Bacteria killed by silver may act as vessels for the metal to kill other pathogens
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FeatureImaging the future
Doctors and pharmaceutical companies are beginning to open their eyes to the power of mass spectrometry imaging, finds Nina Notman
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ResearchSiRNA treatment cures Ebola in monkeys
Researchers perform the first successful trial for a drug against the current strain of Ebola
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ResearchHydrogel with a basic instinct for drug delivery
Gel that releases naproxen in alkaline surroundings is promising step toward relieving drug’s side effects
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ResearchSilicon chip spots dangerous pathogens in human blood
Silicon wafer doped with silver nanoparticles can rapidly identify E. coli in blood