Synthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one

An image showing readily accessible sp3-rich cyclic hydrazine frameworks

Source: © Mike Shipman/University of Warwick

Innovative method amplifies chirality and complexity in medicinally relevant cyclic hydrazines

Scientists in the UK have formulated a new strategy to produce non-planar, heavily substituted heterocyclic scaffolds. The technique makes use of the fluxional behaviour of nitrogen atoms and can synthesise a range of cyclic hydrazine building blocks that could prove useful for drug discovery.