Organic chemistry – Page 31
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ResearchModified metallohelices show medical potential
Post-assembly click reactions on helical metal complexes produces biological activity akin to that of the arrow poison ouabain
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ResearchMechanochemistry bypasses need for solvents in Suzuki coupling
Adding a small amount of olefin dramatically improves challenging solid-state coupling reaction
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ResearchSelf-assembling ‘buckybowls’ inspired by virus capsids
Football-like molecules could be used in drug delivery, catalysis and synthesis
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ResearchAlgorithm increases certainty of stereochemical assignments in flexible molecules
Computational fitting procedure set to reinvigorate vibrational circular dichroism spectroscopy
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OpinionFluorine: the T rex of the periodic table
Pass out the nickel superalloy reactor kit, it’s time to tame that most reactive of elements
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ResearchFirst molecular knots made from just benzene rings
Catenane and trefoil knot are the first mechanically interlocked molecules made from only carbon and hydrogen
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ResearchNew chiral carbene expands ligand reservoir for asymmetric catalysis
Introducing rigidity boosts enantioselectivity
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ResearchAFM captures changing structures of charged molecules
Technique that adds electrons one by one could enable new molecules to be synthesised by atomic manipulation
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OpinionThe silent rise of the robots
Mechanical helpers have been creeping into our labs for decades
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ResearchSelf-deoxygenating glassware is a breath of fresh air for oxygen-sensitive reactions
Lab vials coated with glucose oxidase convert dissolved oxygen into a catalyst for RAFT polymerisation
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ResearchElectric field flicks switch for bond breaking reaction
Proof that electrostatics can selectively power up one reaction in a multistep process
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ResearchFloppiness scale untangles knotted molecules
Chemists use floppiness factor to characterise mechanically interlocked molecules using mass spectrometry
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ResearchNew hypervalent iodine compound is most powerful oxidant in series
2-iodoxybenzoic acid ditriflate can oxidise stubborn hydrocarbons and obstinate polyfluoroalcohols
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Opinion(+)-Microladallene B
A weird structure is enough to spark chemists’ interest, even without any obvious use
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ResearchChiral borane complexes catalyse new synthesis opportunities
N-heterocyclic carbene-borane complexes with a rare stereogenic boron centre demonstrate potential in stereoselective catalysis
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ResearchStudy ranks interactions between hydrogen-bond acceptors and cations
Experiments establish a set of parameters that will help scientists predict the free energies of the interaction between cations and hydrogen-bond acceptors in any solvent with good reliability
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ResearchBaran and Blackmond team up to wave farewell to tough ether syntheses
Oxidative decarboxylation produces carbocations that greatly speed up hindered ether production
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Opinion‘Coffee machine’ synthesiser’s first steps
Cartridge-based machine enables non-experts to make heterocycles
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