Reactions and synthesis – Page 11
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ResearchMashed magnesium used to prepare Grignards without worrying about air
Mechanochemical method avoids inert gas and dry solvents in classic organometallic reaction
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ResearchRare red californium sandwich pushes frontier of isolable molecules
Researchers rehearsed metallocene’s synthesis with other elements before using just two milligrams of the precious radioactive actinide
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ResearchDiels-Alder reaction directly observed under the microscope
Simple ring-forming reaction followed on a surface for the first time using scanning probe microscopy
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ResearchUnsupervised machine-learning tool could accelerate catalyst discovery
The approach was able to identify phosphine ligands that may form dinuclear palladium(I) complexes using only five experimental data points
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ResearchDoubly negative dianions can form π hole bonds too
Researchers report an attractive interaction between two doubly negative dianions for the first time
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ResearchPorous material made by mimicking deep Earth conditions
Extreme temperature changes water’s properties so it can replace organic solvent
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ResearchRecord-breaking hexagon made out of fused aromatic rings
90 rings form the largest structure of its kind ever made
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ResearchDearomatisation, but without nasty reagents
New Birch reduction protocol creates solvated electrons without the dangerous combination of liquid ammonia and alkali metal
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ResearchGlassware found to promote reactions in Miller–Urey 'primordial soup' experiment
By running their famous 1952 experiment in glass flasks, Stanley Miller and Harold Urey might have unintentionally simulated the role of rocks on early Earth
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ResearchAre organic chemists discovering fewer reactions than they were decades ago?
Analysis of millions of transformations reveals reliance on popular methods – and the rise of complex reactions
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ResearchPlasma-based approach leads to more reactive oxygen donors for alkene epoxidation
Yield of epoxidation reaction increased, and waste reduced, by using CO2-derived atomic oxygen and plasma-based conditions
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ResearchClippanes join rotaxanes and catenanes in mechanically interlocked molecule family
Keck-clip molecules consist of two entangled gold–carbene metallotweezers
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ResearchFirst fundamentally new form of adsorption for more than 90 years driven by molecular machines
Unlike physisorption and chemisorption, the newly discovered ‘mechanisorption’ is an active process that can store energy or chemicals
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ResearchCooking oils work as solvents for metal-catalysed reactions
Suzuki–Miyaura, Hiyama, Stille, Sonogashira and Heck cross-couplings shown to proceed with quantitative yields in certain vegetable oils, fish oil, butter and waxes
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ResearchSqueezed crystal becomes better catalyst
Fine-tuning platinum’s lattice strain with removable atomic spacers boosts its catalytic activity by up to 50%
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ResearchExploiting evolution to explore chemical space shows promise for drug discovery
Using molecular trees – similar to family trees – chemists could predict how products will evolve to make new molecules
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ResearchMöbius metallacycles show their aromaticity with textbook reactivity
First electrophilic aromatic substitution reactions with unusual molecules
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ResearchExplainer: why has asymmetric organocatalysis won the chemistry Nobel prize?
In a rather unexpected move by the Nobel committee, this year’s prize in chemistry has been awarded to Benjamin List and David MacMillan
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ResearchPeptide superstructures speed up Michael reaction
A tripeptide that self-assembles into a supramolecular fibres accelerates an asymmetric benchmark reaction by up to 74%
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ResearchUltraphosphates break decades-old anti-branching rule
Discovery of elusive branched phosphates’ unexpected stability means they could have played a role in prebiotic chemistry