Alzheimer’s linked to infection of the brain by gum disease bacterium

An image of P. gingivalis' gingipains in the neurons of Alzheimer's brain

Source: © Cortexyme, Inc.

Drug firm is developing treatment to inhibit bacterial enzymes believed to be damaging important protein

A bacterial infection better known for causing gum disease may be leading to the development of Alzheimer’s disease in some patients by entering the brain and releasing enzymes that attack important proteins. Scientists at the company Cortexyme, working with academics from around the world, say the findings of their study could lead to new treatment options for Alzheimer’s disease sufferers that work by targeting the bacterium Porphyromonas gingivalis, and they have developed a candidate drug that is currently undergoing clinical trials.